Drug Reference
Other
Diphenhydramine
Also: Benadryl
H₁ antihistamine
IndicationAdultPediatric
Anaphylaxis adjunctAdult25–50 mg IV/IM/POPeds1 mg/kg (max 50 mg)
Indications
- Adjunct for anaphylaxis (urticaria, itching)
- Acute dystonic reactions
Contraindications & cautions
- Never a substitute for epinephrine in anaphylaxis
Key pearls
- Does not treat airway obstruction or hypotension
- Sedating; anticholinergic in overdose