Drug Reference
Antidotes
Naloxone
Also: Narcan
Opioid receptor antagonist
IndicationAdultPediatric
Opioid overdoseAdult4 mg IN; 0.4–2 mg IV/IM/IO; repeat every 2–3 minPeds0.1 mg/kg IV (max 2 mg)
Indications
- Opioid-induced respiratory depression
Contraindications & cautions
- None in life-threatening overdose
Key pearls
- Duration (30–90 min) is shorter than many opioids: observe for re-sedation
- Titrate low (0.04–0.1 mg IV) in opioid-dependent patients to restore breathing without precipitating withdrawal
- Never let naloxone delay ventilation or CPR